CALL FOR PAPERS Bioengineering the Lung: Molecules, Materials, Matrix, Morphology, and Mechanics Genetic deletion of IL-17A reduces cigarette smoke-induced inflammation and alveolar type II cell apoptosis
نویسندگان
چکیده
Ying Chang,* Laila Al-Alwan,* Severine Audusseau, Fazila Chouiali, Juna Carlevaro-Fita, Yoichiro Iwakura, Carolyn J. Baglole, David H. Eidelman, and Qutayba Hamid Meakins-Christie Laboratories and Respiratory Division, McGill University Health Centre and Department of Medicine McGill University, Montreal, Quebec, Canada; Center for Translational Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an, China; Research Institute for Biomedical Sciences, Tokyo University of Science, Yamasaki, Japan; and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan
منابع مشابه
Genetic deletion of IL-17A reduces cigarette smoke-induced inflammation and alveolar type II cell apoptosis.
Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder marked by relative resistance to steroids. Inflammation and apoptosis have been suggested to be important mechanisms for COPD. Interleukin (IL)-17 superfamily has been associated with chronic inflammation and diminished responses to steroids. It is reasonable to consider that IL-17 may play a role in the pathogenesis of CO...
متن کاملChinese green tea consumption reduces oxidative stress, inflammation and tissues damage in smoke exposed rats
Objective(s):One cause of cigarette smoking is oxidative stress that may alter the cellular antioxidant defense system, induce apoptosis in lung tissue, inflammation and damage in liver, lung, and kidney. It has been shown that Chinese green tea (CGT) (Lung Chen Tea) has higher antioxidant property than black tea. In this paper, we will explore the preventive effect of CGT on cigarette smoke-in...
متن کاملAsiaticoside attenuates hyperoxia-induced lung injury in vitro andin vivo
Objective(s): Asiaticoside (AS) displays anti-inflammation, and anti-apoptosis effect, but the role of AS in hyperoxia-induced lung injury (HILI) treatment is undefined. Therefore, the aim of this study was to investigate the effects of AS on HILI on premature rats and alveolar type II (AEC II) cells.Materials and Methods: Sprague-Dawley...
متن کاملInnate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette- smoke-induced lung inflammation in mice
Cigarette smoke (CS) is the major cause of chronic obstructive pulmonary disease (COPD). Interleukin-17A (IL-17A) is a pivotal cytokine that regulates lung immunity and inflammation. The aim of the present study was to investigate how IL-17A regulates CS-induced lung inflammation in vivo. IL-17A knockout (KO) mice and neutralization of IL-17A in wild-type (WT) mice reduced macrophage and neutro...
متن کاملCALL FOR PAPERS Bioengineering the Lung: Molecules, Materials, Matrix, Morphology, and Mechanics Rho-kinase inhibition attenuates airway responsiveness, inflammation, matrix remodeling, and oxidative stress activation induced by chronic inflammation
Samantha Souza Possa, Homar Toledo Charafeddine, Renato Fraga Righetti, Patricia Angeli da Silva, Rafael Almeida-Reis, Beatriz Mangueira Saraiva-Romanholo, Adenir Perini, Carla Máximo Prado, Edna Aparecida Leick-Maldonado, Milton A. Martins, and Iolanda de Fátima Lopes Calvo Tibério Department of Medicine, School of Medicine, University of São Paulo, and Department of Biological Science, Federa...
متن کامل